Current Grants
Ohio Cancer Research is proud to have awarded nearly $9 million in new seed money grants. With these foundational investments, OCR has kickstarted the research careers of 176 investigators across 180 projects and helped ensure their future success as they bring new and innovative ideas to the cure, prevention, and treatment of cancer.
2023-2027 Grant Recipients
The Ohio State University
Mengying Hu, PhD
Years: 2025-2027
Grant Awarded: $80,000
Generated: TBD
Cancer Type:
Immunogene Therapy, Immunotherapy
Project:
Chimeric lipid nanoparticles for DNA cancer vaccine development
“Cancer vaccines train the immune system to attack tumors without harming healthy tissue, but conventional approaches often fail to elicit rapid and robust enough responses against aggressive cancers. Funding from OCR will allow us to develop an innovative DNA cancer vaccine platform that generates quick and powerful immune defenses against tumor-specific antigen.”
Funding provided by Kimball Midwest/The McCurdy Family
Metrohealth Medical Center
Xiaojun Shi, PhD
Years: 2025-2027
Grant Awarded: $80,000
Generated: TBD
Cancer Type:
Immunotherapy
Project:
EphA2 Kinase Activity: Novel Modulator for Cancer Immune Evasion
“Immunotherapy has made significant progress in treating a subset of cancer patients. The generous support from OCR will enable us to develop new targets that can synergize with immunotherapy, helping to deliver better outcomes for patients who are not currently responding to treatment.”
Cleveland Clinic
Lai (Linda) Chan, PhD
Years: 2024-2026
Grant Awarded: $80,000
Generated: TBD
Cancer Type:
Leukemia
Project:
Exploiting Pathway Incompatibility for Targeted Therapy in STAT5-Pathway Mutated B-Cell Leukemia
“Despite recent advancements in treatments, approximately 20% of patients with B-cell acute lymphoblastic leukemia experience a return of the disease within two years of initial treatments. Only about half of these patients survive when leukemia returns. Funding from OCR will allow us to explore innovative approaches to treat leukemia and prevent the development of drug resistance. Our research aims to minimize the likelihood of disease recurrence and improve clinical outcomes.”
Funding provided by Kimball Midwest/The McCurdy Family
Cleveland State University
Kailash Gulshan, PhD
Years: 2024-2026
Grant Awarded: $80,000
Generated: TBD
Cancer Type:
Lung Cancer
Project:
Targeting Inflammasome Activity in Lung Cancer
“Lung cancer is the leading cause of cancer-related deaths worldwide, thus novel anti-lung cancer therapeutic approaches are urgently needed. Our research will open novel therapeutic and research avenues for targeting lung cancer. Support from OCR serves as a foundation for this innovative project, aiming to identify pathways that can be targeted to treat lung cancer.”
Case Western Reserve University
Tae Hun Kim, PhD
Years: 2024-2026
Grant Awarded: $80,000
Generated: TBD
Cancer Type:
DNA Damage-Related Cancers
Project:
Structural Insights into PARP2 Interactions within Chromatin for DNA Repair
“Receiving generous support from Ohio Cancer Research empowers our team to push the boundaries of cancer research, paving the way for innovative treatments and achieving an unprecedented level of understanding in cancer biology.”
Nationwide Children’s Hospital
Prajwal Rajappa, MD, MS
Years: 2023-2025
Grant Awarded: $80,000
Generated: $2,821,704
Cancer Type:
Brain Cancer
Project:
IL-12 Secreting Genetically Modified Myeloid Cells and Immune Checkpoint Blockade to Prevent Glioma Malignant Progression
“Our funded project with OCR will focus on utilizing IL-12 secreting myeloid cells and immune checkpoint blockade for the activation of cytotoxic cells to kill glioma cells before they undergo malignant progression. Having the support of OCR is critical for our ability to develop these novel innate immunotherapies.”
Funding provided by Kimball Midwest/The McCurdy Family
Cleveland Clinic Foundation
Mihriban Karaayvaz, PhD
Years: 2023-2025
Grant Awarded: $80,000
Generated: TBD
Cancer Type:
Breast Cancer
Project:
Modulation of mechanosignaling in the prevention of BRCA1/2 mutant breast cancer
“Breast cancer is the most common cancer in females, affecting one in every eight women and accounting for the majority of cancer-related deaths in women worldwide. The generous funding from Ohio Cancer Research will pave the way for our research to receive federal funding and to improve breast cancer patient outcomes by developing novel prevention strategies.”
University of Toledo
Shi-He Liu, MD
Years: 2023-2025
Grant Awarded: $80,000
Generated: $2,490,190
Cancer Type:
Pancreatic Cancer
Project:
Engineering Exosome for Pancreatic Cancer Targeting Therapies
“Pancreatic cancer remains one of deadliest forms of cancer in the United States with a 5-year survival rate of less than 10 percent. The generous funding from Ohio Cancer Research will lay the groundwork for our research to receive federal funding and help to improve outcomes for pancreatic cancer patients.”